Linkage to chromosome 2q32.2-q35 in families with serrated neoplasia

Background Causative genetic variants have to date been identified for only a small proportion of familial colorectal cancer (CRC). While conditions such as Familial Adenomatous Polyposis (FAP) and Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer, HNPCC) are caused by well defined genetic defects, the search for variants underlying the remainder of familial CRC is plagued by genetic heterogeneity. The recent identification of families with a heritable predisposition to malignancies arising through the serrated neoplasia pathway provides an opportunity to study a subset of familial CRC in which genetic heterogeneity may be greatly reduced.